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  • 23.07.2018
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Causes of damaged sperm

Sperm DNA damage is the major cause of defective sperm function. Oxidative DNA damage is an important factor, which affects sperm quality and increases risk of genetic and epigenetic abnormalities. Accumulation of oxidized DNA adducts like 8 hydroxy2deoxyguanosine 8OHdG can impair function of denovo methylases and result in genome wide hypomethylation which compromise genetic stability 2. Thus, loss of sperm DNA integrity not only impacts reproductive and psychological health of the infertile couple but also increases childhood disease burden.
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Sperm DNA damage diagnostics: when and why

Causes of damaged sperm
Causes of damaged sperm
Causes of damaged sperm
Causes of damaged sperm
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High sperm DNA damage a leading cause of 'unexplained infertility', research finds -- ScienceDaily

In an age when a small quantity of sperm can lead to pregnancy through in vitro fertilization or intracytoplasmic sperm injection, selecting healthy sperm is important. Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling TUNEL and the alkaline comet test are SDF tests that directly measure DNA damage and have shown closer correlations with assisted reproduction results than indirect tools such as the sperm chromatin structure assay or the sperm chromatic dispersion test. It is difficult; however, to endorse a single test as the best test overall; instead, it is best to select a testing method based on each patient's clinical condition and goals. In a couple struggling with infertility, if the male partner has a high level of SDF, he should aim to decrease SDF through lifestyle modifications, antioxidant treatment, and ensuring an appropriate duration of abstinence, and physicians need to treat the underlying diseases of such patients. If sperm DNA damage continues despite the patient's and physician's efforts, other methods, such as micromanipulation-based sperm selection or testicular sperm extraction, should be used to select healthy sperm with nuclear DNA integrity. Semen analysis is the most important test for evaluating male infertility, but it does not provide information regarding all functions of sperm, nor is it sufficient for predicting male fertility potential and the likelihood of success of assisted reproductive technology ART [ 2 ]. In other words, it is the minimum standard for pregnancy.
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Learn about Your Sperm

Low sperm count means that the fluid semen you ejaculate during an orgasm contains fewer sperm than normal. A low sperm count is also called oligospermia ol-ih-go-SPUR-me-uh. A complete absence of sperm is called azoospermia. Your sperm count is considered lower than normal if you have fewer than 15 million sperm per milliliter of semen. Having a low sperm count decreases the odds that one of your sperm will fertilize your partner's egg, resulting in pregnancy.
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Up to 15 percent of couples are infertile. This means they aren't able to conceive a child, even though they've had frequent, unprotected sexual intercourse for a year or longer. In over a third of these couples, male infertility plays a role. Male infertility is due to low sperm production, abnormal sperm function or blockages that prevent the delivery of sperm.
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